(Cat. No. 212702) Rabbit Anti-LCAR-B38M Monoclonal Antibody, Alexa Fluor 647, 100 tests
Beschreibung
Description
38-1A2 is a specific antibody that binds precisely to two tandem VHH sequences of LCAR-B38M. These sequences are designed to target two epitopes of the B-cell maturation antigen (BCMA), a protein selectively expressed by B-lineage cells, including both normal and malignant plasma cells in multiple myeloma. Ciltacabtagene autoleucel, also known as cilta-cel or Carvykti, is a gene-edited autologous CAR T-cell therapy that utilizes LCAR and B38M to effectively recognize BCMA-positive cells. The antibody 38-1A2 can be used for detection in the context of CAR T-cell products from Johnson & Johnson and Legend Biotech, which collaborate on the development and commercialization of Carvykti.
Specification
- Size: 100 tests
- Recommended Vol. per test: 1μl
- Antibody Types: Monoclonal
- Antibody Format: Whole IgG
- Clone: 38-1H2
- Immunogen: Two Tandem VHH Sequences of LCAR-B38M
- Conjugate: Alexa Fluor 647
- Excitation/Emission Max: 651/667nm
- Host species: Rabbit
- Application: Flow Cytometry
- Storage buffer: Aqueous buffered solution containing protein stabilizer and ≤0.05% ProClin 300
Preparation and Storage
- Store undiluted at 2-8°C.
- Avoid prolonged exposure to light.
- Avoid freeze/thaw cycle of the reagent.
- The monoclonal antibody was purified by Protein A.
- The antibody was conjugated with Alexa Fluor 647 under optimum conditions, and unincorporated dye was removed.
Product Notices
- Since applications vary, each investigator should titrate the reagent to obtain optimal results.
- Caution: Antibody solutions containing ProClin 300 should be handled with care. Do not take internally and avoid all contact with the skin, mucosa and eyes.