(Cat. No. 213555) Anti-GPC3 CAR Idiotype Antibody, Alexa Fluor 647, 10 tests
Beschreibung
Description
RE9 is a specialized rabbit monoclonal antibody with high specificity for binding to the extracellular domain of the GC33 scFv within Chimeric Antigen Receptors (CARs). The GC33 scFv fragment is derived from a mouse monoclonal antibody that targets Glypican-3 (GPC3), a cell surface antigen implicated in hepatocellular carcinoma (HCC). GPC3's elevated presence in liver cancer is linked to tumor progression and metastasis, underscoring its significance as a biomarker and therapeutic target. Ongoing clinical trials are exploring the potential of GPC3-targeted CAR-T cells in treating HCC.
Specification
- Size: 10 tests
- Recommended Vol. per test: 5μl
- Antibody Types: Monoclonal
- Antibody Format: Whole IgG
- Clone: RE9
- Immunogen: scFv region of a GPC3-specific mouse mAb clone GC3
- Conjugate: Alexa Fluor 647
- Excitation/Emission Max: 651/667nm
- Host species: Rabbit
- Application: Flow cytometry
- Storage buffer: Aqueous buffered solution containing protein stabilizer and ≤0.05% ProClin 300
Preparation and Storage
- Store undiluted at 2–8°C.
- Avoid prolonged exposure to light.
- Avoid freeze/thaw cycle of the reagent.
- The monoclonal antibody was purified by Protein A.
- The antibody was conjugated with Alexa Fluor 647 under optimum conditions, and unincorporated dye was removed.
Product Notices
- Since applications vary, each investigator should titrate the reagent to obtain optimal results.
- Caution: Antibody solutions containing ProClin 300 should be handled with care. Do not take internally and avoid all contact with the skin, mucosa and eyes.