GMP-TL 502 Anti-Human CD20 mAb, 500μg

Product Information

Expression Host: CHO cells

QC Testing Purity: > 90 % as determined by SDS-PAGE

Purification: Protein A purified from cell culture supernatant

Endotoxin: < 0.1EU per 1μg of the protein as determined by the LAL method.

Biological Activity: The binding rate with PBMCs

Formulation: Supplied as a 0.22μm filtered solution in PBS, PH 7.4.

Stability & Storage: 24 months at 2℃ to 8℃. Avoid repeated freeze-thaw cycles.

Background:

CD20 is a specific signature molecule on the surface of B lymphocytes and is expressed on more than 95% of normal or malignant B lymphocytes.

There is no expression of CD20 antigen in hematopoietic stem cells, progenitor cells, and other normal tissues. It consists of 297 amino acids with a molecular weight of 33 kD. CD20 has no internalization or cell surface shedding after binding with anti-CD20 mAb , which is an ideal antigen in the treatdment of B lymphocyte-related diseases. Anti-CD20 mAb can kill most of the lymphoma cells expressing CD20 molecules and normal B cells. Innate normal B cells are not affected by anti-CD20 mAb and can reconstruct B cell population.
Therefore, anti-CD20 monoclonal antibodies are increasingly used in the treatment of B cell-related diseases.