GMP-TL112 Anti-Human CD52 mAb , 100μg

Product Information

Expression Host: HEK293 cells

QC Testing Purity: > 90 % as determined by SDS-PAGE

Purification: Protein A purified from cell culture supernatant

Endotoxin: < 0.1EU per 1μg of the protein as determined by the LAL method

Biological Activity: The binding rate with MC/CAR

Formulation: Supplied as a 0.22μm filtered solution in PBS, PH 7.4.

Stability & Storage: 24 months at 2℃ to 8℃. Avoid repeated freeze-thaw cycles.

Background:

CD52 is a widely distributed antigen belonging to a GPI anchored glycoprotein with only twelve amino acid residues (GQNDTSQTSSPS).
CD52 can be found on the surface of lymphocytes, monocytes,eosophils and dendritic cells in hematopoietic system. with a density of up to 5×105 molecules on lymphocytes, CD52 antigens express on many lymphoid cell malignancies and certain acute myeloid leukemia cells.
When CD52 molecules are crosslinked with mAb, it triggers a series of signaling within the target cells. The signaling caused by the activation of CD52 molecules is similar to that caused by anti-CD3 antibodies.
When CD52 molecules are triggered, PMA (Phorbol Myristate acetate, acetylmyridrobol ester) can promote the proliferation and secretion of cytokines in normal human CD4 + and CD8 + T lymphocytes in vitro.